Patent Details

Patent ID: US888400

Method for the preparation of carbapenam compounds

Description: The subject of the present invention is a method of the preparation of compounds containing the core skeleton of carbapenem antibiotics, novel intermediate compounds used in this method, a method of the preparation of the intermediate compounds as well as the use of the intermediate compounds in the production of carbapenem antibiotics. This application is a U.S. National Phase Application based on International Application PCT/PL2012/050005 filed Feb. 14, 2012, which claims priority to Poland Application No. P. 393916 filed Feb. 14, 2011. The disclosures of both applications are incorporated herein by reference in their entirety. The present invention relates to a method of the preparation of compounds containing the core skeleton of carbapenem antibiotics, novel intermediate compounds used in this method, a method of the preparation of the intermediate compounds as well as the use of the intermediate compounds in the production of carbapenemate antibiotics. Thienamycin (1) is the best known, natural carbapenem antibiotic with a high pharmacological activity. Derivatives of thienamycin such as Imipenem (2), Panipenem (3), Doripenem (4), Meropenem (5), Ertapenem (6), Biapenem (7), Razupenem (8) are the active ingredients of known pharmaceutical therapeutics with anti-inflammatory activity, and high resistance to β-lactamases, bacterial enzymes that destroy administered antibiotics.

Patent Details: http://www.google.com/patents/US8884005

DOI: PCT (WO2012112061), EP (EP12716705.4), US (US8884005)